Acetaminophen Poisoning

Acetaminophen is one of the most popular nonnarcotic analgesic–antipyretic agents available. Inappropriate use of this agent can lead to significant morbidity and mortality secondary to hepatic necrosis. Several patient-specific factors impact its metabolism and the subsequent production of its toxic metabolite when consumed in excess. Rapid diagnosis and treatment with N-acetylcysteine in the first few hours following overdose is imperative in preventing permanent hepatic damage and death. It is essential for all health care providers to be familiar with the etiology and progression of this poisoning, as well as the necessary steps in treatment, to provide the highest level of care for this often-treatable condition.